| Expression System | E.coli |
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| Protein Tag | No tag |
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| Purity | > 95% by SDS-PAGE under reducing conditions |
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| Endotoxin | < 0.05 EU per ug by the LAL method |
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| Activity | Positive |
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| Conjugate | Unconjugated |
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| Species | Human |
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| Accession Number | AAC08706 |
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| Protein Sequence | Ala20-Phe152 |
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| Molecular Weight | The protein has a predicted MW of 15 kDa and migrates at approximately 16 kDa on SDS-PAGE with DTT-reduced condition. |
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| Formulation | Lyophilized powder from 0.22um filtered solution in PBS, pH 7.4, 8% trehalose |
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| Purification | SEC |
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| Applications | ELISA |
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| Format | Lyophilized |
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| Reconstitution | Centrifuge the tube before opening. Recommend reconstitute to a concentration > 100 ug/ml |
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| Shipping Condition | Ambient |
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| Storage/Shelf Life | <-20 °C for 12 months from the date of receipt; -80°C for 3 months after reconstitution. |
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| Background Information | Interleukin-18 (IL-18) is a pro-inflammatory cytokine that plays a crucial role in innate and adaptive immunity. It belongs to the IL-1 cytokine family and is primarily produced by macrophages and dendritic cells. IL-18 functions by binding to the IL-18 receptor (IL-18R), leading to activation of NF-κB and MAPK signaling pathways, which promote IFN-γ production and enhance Th1 immune responses. |
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