| Expression System | E.coli |
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| Protein Tag | No tag |
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| Purity | > 90% by SDS-PAGE under reducing conditions |
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| Endotoxin | < 1 EU per ug by the LAL method |
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| Activity | Positive |
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| Conjugate | Unconjugated |
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| Species | Human |
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| Accession Number | P70380-1 |
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| Protein Sequence | Asn36-Ser192 |
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| Molecular Weight | The protein has a predicted MW of 18 kDa and migrates at approximately 19 kDa on SDS-PAGE with DTT-reduced condition. |
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| Formulation | Lyophilized powder from 0.22um filtered solution in PBS, pH 7.4, 22% trehalose |
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| Purification | SEC |
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| Applications | ELISA |
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| Format | Lyophilized |
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| Reconstitution | Centrifuge the tube before opening. Recommend reconstitute to a concentration > 100 ug/ml |
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| Shipping Condition | Ambient |
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| Storage/Shelf Life | <-20 °C for 12 months from the date of receipt; -80°C for 3 months after reconstitution. |
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| Background Information | Interleukin-18 (IL-18) is a pro-inflammatory cytokine belonging to the IL-1 family, playing a crucial role in innate and adaptive immunity. It is primarily produced by macrophages, dendritic cells, and epithelial cells. IL-18 binds to the IL-18 receptor (IL-18R) and, in combination with IL-12, enhances IFN-γ production from NK cells and T cells, promoting a Th1 immune response. It also influences inflammatory pathways in autoimmune diseases and cancer. |
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