| Expression System | HEK293 |
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| Protein Tag | N-FLAG tag and C-His tag |
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| Purity | > 95% by SDS-PAGE under reducing conditions |
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| Endotoxin | < 1 EU per ug by the LAL method |
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| Activity | Positive (Tested by ELISA and Flow cytometry) |
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| Conjugate | Unconjugated |
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| Species | Human |
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| Accession Number | Q9UHE8 |
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| Protein Sequence | Met1-Leu339 |
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| Molecular Weight | The protein has a predicted MW of 43 kDa. |
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| Formulation | 0.22um filtered solution in PBS, pH 7.4, 300mM L-Arginine |
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| Purification | Ni |
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| Applications | ELISA |
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| Format | Liquid |
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| Reconstitution | NA |
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| Shipping Condition | Dry ice |
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| Storage/Shelf Life | < -80°C for 6 months |
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| Background Information | STEAP1 (Six-Transmembrane Epithelial Antigen of the Prostate 1) is a cell-surface protein primarily expressed in prostate tissue and overexpressed in multiple cancer types, including prostate cancer, bladder cancer, and Ewing sarcoma. It belongs to the STEAP family of metalloreductases, although unlike other members, STEAP1 lacks key enzymatic motifs and is believed to function more as a transporter or signaling molecule. Due to its tumor-specific overexpression and surface localization, STEAP1 is a highly promising target for cancer immunotherapy, including monoclonal antibody therapies, CAR-T cell development, and cancer vaccines. |
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